1 基本信息

张晓慧 工学博士

西安交通大学，生命科学与技术学院，副教授

xiaohuizhang@mail.xjtu.edu.cn

2 教育经历

1997.09～2001.07：大连理工大学，化学工程，工学学士；

2001.09～2004.07：中科院大连化学物理研究所，生物化工，工学硕士；

2004.09～2009.05：美国塔夫茨大学，生物技术，工学博士；

3 工作经历

2009.09～2013.03：美国哈佛大学－麻省理工学院健康科学与技术部，哈佛大学医学院，博士后；

2013.09～至今：西安交通大学，生命科学与技术学院，副教授；

4 研究领域

新型生物材料的开发与应用；

工程化组织器官及疾病模型的体外构建；

生殖医学工程声波器件的波动特性分析；

细胞冷冻保存等生物医学工领域中的应用

5 代表性论文、专利、著作等

1.    Y. Han, S. Wang, X. Zhang, Y. Li, G. Huang, H. Qi, Y. Li, B.P. Murphy, T. Lu, F. Xu*, Engineering Physical Microenvironment for Stem Cell based Regenerative Medicine, Drug Discovery Today, 2014, doi: 10.1016/j.drudis.2014.01.015. (IF 6.551)

2.    Y. Li, G. Huang, X. Zhang, L. Wang, Y. Du, T. Lu, F. Xu, Engineering cell alignment in vitro, Biotechnology Advances, 2014, 32(2):347-65. (IF 9.599)

3.     S. Tasoglu, H. Safaee, X. Zhang, J.L. Kingsley, P.N. Catalano, U.A. Gurkan, A. Nureddin, E. Kayaalp, R.M. Anchan, R.L. Maas, E. Tüzel, U. Demirci, Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting, Small, 2013, 9(20):3374-84 (IF 7.823)

4.    Y. Li, G. Huang, X. Zhang, B. Li, Y. Chen, T. Lu, TJ. Lu, F. Xu, Magnetic hydrogels and their potential biomedical applications, Advanced Functional Materials, 2013, 23(6): 660-72. (IF 9.765)

5.    G. Huang, S. Wang, X. He, X. Zhang, TJ. Lu, F. Xu, Helical spring template fabrication of cell-laden microfluidic hydrogels for tissue engineering, Biotechnology and Bioengineering, 2013, 110(3): 980-9. (IF 3.648)

6.    G. Huang, X. Zhang, Z. Xiao, Q. Zhang, J. Zhou, F. Xu, T. Lu, Cell-encapsulating microfluidic hydrogels with enhanced mechanical stability, Soft Matter, 2012, 8 (41), 10687-94. (IF 3.909)

7.    X. Zhang, I. Khimji, L. Shao, H. Safaee, K. Desai, H.O. Keles, U.A. Gurkan, E. Kayaalp, A. Nureddin, R.M. Anchan, R.L. Maas, U. Demirci, Nanoliter droplet vitrification for oocyte cryopreservation, Nanomedicine, 2012, 7(4): 553-64. (IF 5.26)

8.    X. Zhang, P.N. Catalano, U.A. Gurkan, I. Khimji, U. Demirci, Emerging technologies in medical applications of minimum volume vitrification, Nanomedicine, 2011, 6(6), 1115-29. (IF 5.26)

9.   X. Zhang*, I. Khimji*, U.A. Gurkan, H. Safaee, P.N. Catalano, H.O. Keles, E. Kayaalp, U. Demirci, Lensless imaging for simultaneous microfluidic sperm monitoring and sorting, Lab on a chip, 2011, 11, 2535-40. (IF 5.697)

10.    J. Samot, S. Moon, L. Shao, X. Zhang, F. Xu, Y. Song, H.O. Keles, L. Matloff, J. Markel, U. Demirci, Blood banking in living droplets, PLoS ONE, 2011, 6(3): e17530. doi:10.1371/journal.pone.0017530. (IF 3.73)

11.    X. Hu, Q. Lu, L. Sun, P. Cebe, X. Wang, X. Zhang, D.L. Kaplan, Biomaterials from ultrasonication-induced silk fibroin-hyaluronic acid hydrogels, Biomacromolecules, 2010, 11(11): 3178-88. (IF 5.371)

12.    H. Geckil, F. Xu, X. Zhang, S. Moon, U. Demirci, Engineering hydrogels as extracellular matrix mimics, Nanomedicine, 2010, 5(3): 469-84. (IF 5.26)

13.    S. Wharram, X. Zhang, S. McCarthy, D.L. Kaplan, Electrospun silk material systems for wound healing. Macromolecular bioscience, 2010, 10(3): 246-57. (IF 3.742)

14.    F. Xu, S. Moon, X. Zhang, L. Shao, Y. Song, U. Demirci, Multi-scale heat and mass transfer modeling of cell and tissue cryopreservation, Philosophical Transactions of the Royal Society A, 2010, 368, 1–23. (IF 2.891)

15.    Q. Lu, X. Zhang, X. Hu, D.L. Kaplan, Green Process to Prepare Silk Fibroin/Gelatin Biomaterial Scaffolds, Macromolecular bioscience, 2010, 10(3): 289-98. (IF 3.742)

16.    S. Lu, X. Wang, Q. Lu, X. Zhang, J. Kluge, N. Uppal, F. Omenetto, D.L. Kaplan, Insoluble and Flexible Silk Films Containing Glycerol. Biomacromolecules, 2010, 11(1): 143-50. (IF 5.371)

17.    X. Zhang, X. Wang, V. Keshav, X. Wang, J. Johanas, G. Leisk, D.L. Kaplan, Dynamic culture conditions to generate silk-based tissue-engineered vascular grafts. Biomaterials, 2009, 30(19): 3213-23. (IF 7.604)

18.    X. Zhang, M.R. Reagan, D.L. Kaplan, Electrospun silk biomaterial scaffolds for regenerative medicine. Advanced Drug Delivery Review, 2009, 61(12): 988-1006. (IF 12.888)

19.    X. Wang, X. Zhang, L. Sun, B. Subramanian, D.L Kaplan, C. Sonnenschein. Preadipocytes stimulate ductal morphogenesis and functional differentiation of human mammary epithelial cells in 3D silk. Tissue Engineering, 2009, 15(10): 3087-98. (IF 4.065)

20.    X. Wang, E. Wenk, X. Zhang, L. Meinel, G. Vunjak-Novakovic, D.L. Kaplan, Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering. Journal of Controlled Release, 2009, 134(2): 81-90. (IF 7.633)

21.    X. Zhang, C.B. Baughman, D.L. Kaplan, In vitro evaluation of electrospun silk fibroin scaffolds for vascular cell growth, Biomaterials, 2008, 29(14): 2217-27. (IF 7.604)

22.    X. Wang, X. Zhang, J. Castellot, I. Herman, M. Iafrati and D.L. Kaplan, Controlled release from multilayer silk biomaterial coatings to modulate vascular cell responses, Biomaterials, 2008, 29(7): 894-903. (IF 7.604)

23.    L. Soffer, X. Wang, X. Zhang, J. Kluge, L. Dorfmann, D.L. Kaplan, G. Leisk, Silk-based electrospun tubular scaffolds for tissue-engineered vascular grafts, Journal of Biomaterials Science, Polymer Edition, 2008,19(5): 653-664. (IF 1.7)

24.    雄鹰, 张晓慧, 梁丰, 郭昕, 王为, 马小军, 分离纯化牛嗜铬细胞方法改进, 中国组织工程研究与临床康复, 2007, 11(12): 2219-2222,2232. (IF 0.668)

25.    X. Zhang, W. Wang, W. Yu, Y. Xie, X. Zhang, Y. Zhang, X. Ma, Development of in vitro multicellular tumor spheroid model using microencapsulation and its application in anticancer drug screening and testing, Biotechnology Progress, 2005,21(4): 1289-96. (IF 1.853)

26.    张晓慧, 王为, 于炜婷, 雄鹰, 张旭朗, 张英, 马小军, Percoll非连续等密度梯度离心法纯化牛肾上腺嗜铬细胞, 解剖学杂志, 2005, 28(1): 234-236. (IF 0.44)

27.    赵心清, 张晓慧, 白凤武,谢健, 李宁，水杨酸信号转导因子对高山红景天悬浮细胞苯丙氨酸氨解酶及红景天甙生产的影响，精细与专用化学品，2002 (s): 74-77. 

专利